Experimental Cancerdialysis new article
Author: Sture Hobro
In a new article, we simulated hashtagCancerdialysis in silico to see the effect from CancerDialysis and conducted some experiments with CancerDialysis in rats.
Link to article: https://lnkd.in/dkgzMiSm
The simulated flow rates of ketones and glucose to blood are significantly higher than the previously reported production capacities. However, no study in the past has removed both glucose and ketones simultaneously, forcing the liver to produce ketones. The rat experiment, where we actively removed both ketones and glucose with dialysis, showed an increase in blood ketones (not scientifically significant), despite the removal of ketones in the dialysate circuit and there was a significant reduction in glucose.
All in all, this article adds more meat to the bones that the mechanism described earlier around CancerDialysis. This new knowledge give us guidelines on how to conduct future research.
The figure below is a combination of figures four and five from the article from the simulations, showing the difference in glucose levels when insulin is removed or not in the dialyzer. Besides the huge difference between dialysis and no dialysis in the left figure, an important effect from the removal of insulin is in play (magenta colors). If insulin is not removed in the dialyzer or compensated for, it has a dramatic effect on the outcome of glucose levels and a minor effect on the ketone levels in the blood.
