The authors of this article made a pioneering discovery! My compliments to the authors of: Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
Did you know that glucose is the primary fuel for most cancers! Reducing glucose in the blood is challenging when the liver produces glucose when glucose levels drop and healthy cells reduces it’s glucose use when levels drop.
Hemodialysis is the most common form of kidney dialysis and is typically given as a four-hour treatment in-hospital thrice weekly to more than 2 million end-stage kidney disease patients worldwide.
As described in post 15, the ketogenic diet (KD) and intermittent fasting have been proven to be good adjuvant therapies to traditional cancer treatments. The mechanism behind this is that these diets interfere with cancer’s ability to handle oxidative stress and escape immune responses.
Even if there is no proof yet, at least important circumstantial evidence is pointing in the direction that it will be possible to create asymptomatic hypoglycemia with Cancerdalysis.
Metabolomics has become a significant field in cancer research.
Today’s dialyzer is permeable to molecules up to 40-50 kD (kilo Daltons), and the insulin molecule is around 6 kD. Therefore, both insulin and glucose are largely removed with modern dialyzers.
In a new article, we simulated Cancerdialysis in silico to see the effect from CancerDialysis and conducted some experiments with CancerDialysis in rats.
Hypoglycemia is thought to occur when blood glucose levels are under 70 mg/dL (3.9mmol/l) for diabetic patients and for healthy patient the level is set to 50 mg/dl (2.8 mmol/l). Typically, hypoglycemia occurs during diabetes treatment when insulin is injected, and glucose levels are low. Severe symptoms and even death can occur typically in diabetic patients.
Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung and Pancreatic Cancer: The University of Iowa Experience of Two Phase I Clinical Trials - PMC
Even though the consequences of the Warburg effect (overutilization of glucose also in the presence of oxygen) have been meticulously researched, and it has been more than 100 years since it was first described, the fundamental cause of the Warburg effect in cancer seems to be a mystery. We will describe our view of the most probable cause for this effect to arise.
Everyone knows about hybrid cars that can be fueled either with electricity or gas. Few know that this is also true for human cells, which can work on glucose extracted from carbohydrates or ketones extracted from fat when glucose is scarce.
Cancer cells, and they have a huge demand for glucose, which they use to boost their survival. This increased glucose uptake is followed by an increased dependence on ATP production through fermentation.
When starving or eating a ketogenic diet and moving into ketosis, the substrate used for ATP generation will shift from primarily glucose in a normal state to ketones during ketogenic condition.
When healthy cells shift to ketone bodies as fuel for energy production it is linked to reduced oxidative stress. Firstly, the need to utilize NAD+ (another substance that can reduce ROS) to produce acetyl-CoA when ketone bodies are used to feed the Krebs Cycle is reduced compared with that when using glycolysis.
It is difficult to predict with certainty which type of cell death will occur in response to a cancer therapy
Ferroptosis is a type of cell death that is of outstanding importance for the function of radiotherapy and chemotherapy in cancer treatment.
Cancer cells can evade apoptosis, which is the process of programmed cell death. This is one of the hallmarks of human cancers that promote tumor formation and progression as well as treatment resistance.
Hyperthermia is used for centuries as a remedy for a range of conditions. Today whole-body hyperthermia is recognized as an effective adjunct in the treatment of many cancers.
Many studies show compelling treatment results when cancer treatments are performed during fasting conditions. It seems that even occasional sessions of fasting can have an extraordinary effect.
This week Cancerdialysis is entering its first Cancer Conference. We are here to learn and spread the word about this totally novel suggestion for how to treat cancer. The reception is mixed.
The accelerated metabolism in cancer cells produces a large amount of Reactive Oxygen Spices (ROS) that is countered (redox balance) by an increased utilization of glutathione that needs NADPH for antioxidant production.
I will participate in the Turin cancer conference 12-15/6 around innovative Cancer Science.
Glioblastoma multiforme is an aggressive brain tumor which may be a good alternative for a CancerDialysis trial. The median survival rate for GBMs when all cases are considered is 12-18 month with today’s treatment practice.
The Ketogenic diet (KD) and Intermittent fasting diet have been studied as adjuvant therapies in cancer treatment. The KD has shown antitumor effects by reducing energy supplies (glucose) to cancer and other effects.
Inhibition of HDACs to reverse epigenetic alterations in cancer has been shown to induce powerful anticancer properties. The combination of HDAC inhibitors with standard chemotherapeutic drugs has demonstrated promising anticancer effects in clinical studies.
Epigenetic changes are understood to play a crucial role in the development and survival of cancer cells. Abnormal epigenetic modifications in specific oncogenes and tumor suppressor genes can result in uncontrolled cell survival, growth, and division
CancerDialysis induces multiple anti-cancer effects. These effects include metabolic, redox, immunologic, and epigenetic effects. Besides reducing oxidative stress in healthy cells, CancerDialysis can help remove toxic metabolites from the blood that are produced by cancer cells and reduce the side effects of chemotherapy.
Blood glucose is limited in the blood (typically only around 5 grams) and must be constantly supplied by the liver. The liver’s ability to supply glucose will quickly be reduced when CancerDialysis is applied.
CancerDialysis will have the ability to flip the metabolic condition in a cancer patient and enforce a starvation-like condition/ketogenic condition by removing glucose, glutamine, and other amino acids and simultaneously increase ketone levels in the blood.
CancerDialysis can reduce epigenetic overexpression (which promotes, for example, immortality in cancer cells) seen in most, if not all, cancers while simultaneously pulling the rug out from under the handling of the increased oxidative stress seen in most cancers.
The production of oxidative stress/free radicals is increased in cancer cells and is an important treatment opportunity used by both radio and chemotherapy.
Here a video (2 minutes long) on how short fasting period affected mice with and without chemotherapies. The results is mesmerizing!
How to use metabolic switching to fight cancer through epigenetic changes? CancerDialysis?
Overall, evidence in support of a beneficial effect of Time Restricted Eating (TRE) in the context of cancer is limited but encouraging.
I found the result quite revealing. To stay away from large amount of starch and fructose before, during and after cancer surgery may be a good idea.
Just found an almost archeologic reference to how dialysis without glucose in dialysate effect the metabolic conditions in dialysis patients during dialysis.
Our article “Dialysis as a Novel Adjuvant Treatment for Malignant Cancers” is topping the list over Highly Accessed Article in the journal Cancers. In total Cancers have close to 20 000 articles so a bit of an achievement.
