CancerDialysis and cell death
Author: Sture Hobro
It is difficult to predict with certainty which type of cell death will occur in response to a cancer therapy. The specific type of cell death after treatment will depend on several factors including type, therapy dose, oxygen availability, nutrition availability, presence of different oncogenes as P53, DNA repair capacity, cell cycle phase and the microenvironment of the tumor will affect what type of cell death that occur. Inside one tumor many of the parameter will differ and one type of death may occur in one part of the tumor and an other in other parts of the tumor.
Therefore, it may be wise to design therapies that are multifactorial to their nature without too many side effects on healthy cells.
Dialysis has been proven to be a treatment with small side effects and can be performed every second day for many years sometimes decades in dialysis patients also in very fragile patients. CancerDialysis is a treatment similar to normal dialysis without glucose (as done almost in every second dialysis treatment) and is only suggested to be used once or twice weekly for a period of 5-10 weeks. This treatment is designed to give small side effects on healthy cells. On the other hand, cancer cells under treatment seem to depend on glucose and glutamine for their defense in order to avoid cell death. This includes many types of potential cell death such as apoptosis, ferroptosis, necrosis and phagocytosis.
Why don’t healthy cells die more during CancerDialysis? You have a clue? If you want to know stay tuned!
Many of our earlier post around CancerDialysis discuss cancer cell death and their link to:
Ferroptosis post 24
Apoptosis post 23
Hypothermia post 22
Glucose loading post 3, 21,
HDAC inhibition post 9, 13 and 14,
Glucose and glutamine levels Post 8,
Immune induced death post 7
Oxidative stress post 6
Ketgenic diet post 5
Intermittent fasting post 4
Figure shows how different type of cell death in cancer cells will be more pronounced during treatment with CancerDialysis.
