Epigenetic switching through the force of CancerDialysis!
Author: Sture Hobro
Epigenetic changes are understood to play a crucial role in the development and survival of cancer cells. Abnormal epigenetic modifications in specific oncogenes and tumor suppressor genes can result in uncontrolled cell survival, growth, and division. In cancer, epigenetic alteration is primarily induced by HDAC overexpression.
CancerDialysis will enforce pronounced ketogenic conditions, and ketones are known to be a physiological pan-HDAC inhibitor and may reverse many epigenetic alterations in cancer cells.
Figure: During CancerDialysis, ketone levels will be increased, and glucose levels decreased. However, the abundance of ketones during CancerDialysis will reduce glycolysis and glutaminolysis directly. Further, the reversal of epigenetic alteration through the inhibiting effect of HDACs will further reduce cancer’s ability to survive during CancerDialysis.
