CancerDialysis and the liver interaction
Author: Sture Hobro
Blood glucose is limited in the blood (typically only around 5 grams) and must be constantly supplied by the liver. The liver’s ability to supply glucose will quickly be reduced when CancerDialysis is applied.
CancerDialysis will remove all free small water-soluble substances present in the plasma. This includes glucose, glutamine, other amino acids (AA), and ketones.
Figure Text A; When the energy substrate levels are reduced in the blood trough the dialyzer, B; the liver will respond due to a number of signaling mechanisms to increase the energy levels in the blood with the substrate available. C; However, the reduction of glutamine and other AA will restrict substrates needed for effective gluconeogenesis. D; Therefore, the liver must depend more on fat and produce ketones to uphold the ketone levels in the blood.
Ketones will be removed in a similar percentage in the dialyzer as glucose etc. However, the turnover rate of ketones from liver to cells in the body is faster than for glucose resulting in a lower blood concentration of ketones (gram/dl) than for glucose resulting in slower removal of ketones than glucose in the dialyzer.
E; All in all CancerDialysis promotes a quick switch from normal metabolic condition with high glucose concentration in the blood to fasting like condition with very low glucose levels and high ketone levels in the blood.
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