Metabolic flipping with Cancerdialysis
Author: Sture Hobro
CancerDialysis will have the ability to flip the metabolic condition in a cancer patient and enforce a starvation-like condition/ketogenic condition by removing glucose, glutamine, and other amino acids and simultaneously increase ketone levels in the blood. Both healthy cells and cancer cells must rapidly adapt to these new conditions. Dialysis without glucose shows that this adaptation is easy for dialysis patients!
Glucose, glutamine, and some other amino acids are essential not only for cancer’s proliferation but also for cancer cells’ survival. The latter is even more important during other cancer therapies such as radiotherapy, chemotherapy, or immunotherapy with the aim of killing cancer cells. Using CancerDialysis in conjunction with those therapies may provide an extra force that breaks the tumors survival ability.
The levels of glucose, glutamine and other amino acids can be controlled by infusion or by adding to the dialysis fluid to ensure that levels do not become too low. Note, this type of dialysis treatment without glucose is still common in many countries in the world today (historically the only treatment) and does not lead to discomfort/side effects.
Link:
Cancers | Free Full-Text | Dialysis as a Novel Adjuvant Treatment for Malignant Cancers (mdpi.com)
Figure: Schematic view of cancer during normal metabolic condition and CancerDialysis condition. A. Cancer cells have typically developed during metabolic conditions where availability of glucose, glutamine and other amino acids has been abundant. B. It is well known that the levels of these substances drop during starvation or starvation mimicking diets. Many studies show that cancer treatments work better during those conditions or that cancer progression is greatly reduced.
