Revive immune response in cancer with Cancerdialysis
Author: Sture Hobro
CancerDialysis can reduce epigenetic overexpression (which promotes, for example, immortality in cancer cells) seen in most, if not all, cancers while simultaneously pulling the rug out from under the handling of the increased oxidative stress seen in most cancers. A third potential mechanism of CancerDialysis is its effect on immune response.
Intermittent fasting has been shown to increase the effect of immune checkpoint blockers and has also indicated that intermittent administration of ketone bodies may have similar effects as ketogenic diet or starvation. This suggests that using CancerDialysis to enforce pronounced ketogenic conditions a one to two times per week (without diet or starvation) may improve the response from our immune system and promote our leukocytes to kill cancer cells (see figure).
Targeting glutamine metabolism, which is the second most important fuel beside glucose in cancer cells, leads to wide-ranging metabolic inhibition, disruption of NADP(H) homeostasis, and stymied growth in cancer. Conversely, targeting glutamine metabolism in T cells leads to adaptive metabolic reprogramming with enhanced survival, proliferation, and effector function (Leone, Science 2019)
Another opportunity created with dialysis is to optimize the buffer capacity in cancer patients by increasing systemic bicarbonate levels. Increased systemic buffer capacity (i.e., increased bicarbonate) also increases local buffer capacity and increases pH in the TME—and has been shown to enhance immunotherapy response.
Taken together it is clear that the opportunity to induce a better immune response is an important potential from CancerDialysis.
Link to CancerDialysis article
https://lnkd.in/ezNz9WaE
