Killing cancer with oxidative stress by CancerDialysis
Author: Sture Hobro
The production of oxidative stress/free radicals is increased in cancer cells and is an important treatment opportunity used by both radio and chemotherapy. Both increase oxidative stress in cancer cells to a point where the cancer cells can’t deal with the increased oxidative stress and die.
Cancer cells use glutathione as their most important hub to deal with oxidative stress in contrast to healthy cells that mainly use other pathways to deal with oxidative stress. NADPH is necessary to renew glutathione when it is used to reduce oxidative stress. However, over time glutathione is consumed and must be reproduced. To do that, three amino acids are needed (see figure A).
CancerDialysis will reduce glucose, glutamine, and other amino acids and thereby erode the functionality in the glutathione reduction process of oxidative stress, which has an indispensable role in maintaining redox hemostasis in cancer cells. Therefore, it is likely to believe that CancerDialysis from a theoretical construct may greatly enhance cancer therapies that work by increasing the oxidative stress in cancer cells e.g. Radio and Chemo therapies (see figure B).
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