Induction of Therapeutic Hypoglycemia with Cancerdialysis
Author: Sture Hobro
Even if there is no proof yet, at least important circumstantial evidence is pointing in the direction that it will be possible to create asymptomatic hypoglycemia with Cancerdalysis. It will be important to develop another secondary fuel (e.g., ketones) that can take over the energy needs for all healthy cells, but not work as fuel for cancer cells.
During an initial phase, glucose levels will drop to 3-4 mmol/L. However, when insulin levers fall, it looks like glucose production in the liver will first increase and glucose levels will have difficulty falling below 3-4 mmol/L.
Therefore, when ketone levels are raised in the blood, a careful infusion of insulin starts to counteract the loss in the dialyzer to ensure more physiological levels of insulin. With no infusion insulin drops during dialysis and the production of insulin is low, so these levels fall extremely during dialysis.
If small doses of insulin are infused to restore more normal physiological levels, this will counteract the gluconeogenesis in the liver and when this happens, the glucose levels will drop to very low levels.
Potentially, to ensure a minimal level of glucose in blood, either low levels of glucose (1-3 mmol/L) or perhaps very low levels (0.5-1 mmol/L) can be present in the dialysate or via infusion added to the circulating blood.
To be continued...
